STAT3 and neoplasm: Next, we evaluated the expression of the NF-κB/STAT3-regulated downstream proteins Cyclin D1 and c-Myc, which are involved in tumor cell proliferation, Bcl-2 and XIAP, whose overexpression is closely related to tumor survival and chemoresistance, and MMP-9 and MMP-2 that are associated with tumor invasion and metastasis.