Following radiotherapy (XRT), OXPHOS is upregulated and assists the remaining viable cancer cells with metabolic demands.7 8 In this manner, XRT can have deleterious effects on the tumor microenvironment, although it carries the unique advantage of overcoming PD-1 resistance by releasing tumor-associated antigens, activating type 1 interferon (IFN) signaling, and inducing antitumor immunity.9 This evidence concerns the gene IFNA1 and neoplasm.