MYC and hepatocellular carcinoma: The miR-106b-25 cluster appears to play an important role in HCC, as it is overexpressed during the development of cirrhosis and subsequently during the development of HCC.47 48 We previously reported that miR-25–3 p is an HCC-originated miRNA that can be secreted into the serum and that miR-25–3 p levels were increased >25-fold in patients with HCC when compared with healthy controls.49 In the present study, we found increased levels of miR-25–3 p in HCC monocytes, which we postulate to have originated from two sources: from monocytes (promoted by c-MYC activation) and from exosomes.