PTPRO and neoplasm: The increased serum IL-6 activated STAT3/c-MYC signaling in peripheral monocytes, enhanced the transcription of miR-25–3 p, suppressed PTPRO expression, promoted PD-L1 through both JAK2/STAT3/c-MYC and JAK2/STAT1 signaling, and promoted tumor growth by enhancing T-cell exhaustion (figure 7).