Although to a much lower extent than regular NANOG, expression of the human-specific NANOGP8 retrogene, often expressed in human cancers (Jeter et al., 2009; Jeter et al., 2011; Zhang et al., 2013, 2006), was also slightly induced by the reprograming process in a STAT3-dependent manner. Here, NANOGP8 is linked to cancer.