In summary, activation and binding of STAT3 to the NANOG promoter during reprogramming and attenuated upregulation of NANOG expression in AD-HIES fibroblasts in combination with decreased reprogramming efficiency of AD-HIES fibroblasts to iPSC suggest that upregulation of NANOG during reprograming through overexpression of OKSM factors in human skin fibroblasts is regulated by endogenous STAT3. The gene discussed is STAT3; the disease is Alzheimer disease.