NANOGP8 is expressed in many cancers (Jeter et al., 2009, 2011; Zhang et al., 2013) and its ability to substitute for NANOG in reprograming activity (Palla et al., 2014), prompted us to analyze the relative contribution of NANOG and NANOGP8 in STAT3-dependent upregulation of total NANOG during our reprogramming procedure (Figs 5 and 6). This evidence concerns the gene NANOGP8 and cancer.