It is noteworthy that the higher expression of the genes exclusively expressed in the C4 B cell types, such as MS4A1 (also known as CD20 antigen), were positively with favorable prognosis of NSCLC (Fig. 1e, f), suggesting a tumor-suppressive function of C4 cells in the microenvironment of NSCLC. This evidence concerns the gene MS4A1 and non-small cell lung carcinoma.