As shown in Fig. S1D, Bmi-1, miR-27a, and miR-155 were significantly upregulated, while RKIP was downregulated in GC, which is consistent with Fig. 1e and Fig. S1A. We divided the patients with available histological information from TCGA into two groups by Lauren classification (intestinal-type and diffuse-type) [21]. The gene discussed is BMI1; the disease is gastric cancer.