Interesting enough, our one patient who received neoadjuvant thearpy prior to resection of their cancer (CRC119) was found to be responsive to an irinotecan therapy and simlary her cell and PDX were also found to be sensitive to irinotecan (Fig. 2) In addition to our evaluation of standard-of-care agents, our high-throughput drug screening using matched cell lines allowed us to discover several pathways of interest, including FGFR, PDGFR, and VEGFR, all of which may contribute to CRC growth. Here, KDR is linked to colorectal carcinoma.