SET and colorectal carcinoma: In order to demonstrate the potential therapeutic value of the miR-199b/SET axis, we generated an acquired resistant model of CRC cells to 5-FU observing that both miR-199b overexpression and genetic or pharmacologic SET inhibition are able to overcome 5-FU resistance (Figure 4), which suggests that these alterations could serve as novel targets for alternative therapeutic strategies in LARC patients with a lack of response to standard preoperative CRT.