The lack of any autoimmune events related to AR-directed therapy administered for CRPC could be explained to by the crucial role of the induction of strong anti-tumor CD8+ T cell responses with a concomitant increase in CD4+CD25+FoxP3+ Tregs following castration [17], which are mainly involved in the suppression of autoimmune manifestations. This evidence concerns the gene FOXP3 and neoplasm.