Firstly, not all CpGs located in the promoter islands of genes could exert a significant control in the transcription in lung cancer, so the evaluation of methylation status of each single CpG of SPARC in non-neoplastic and tumor tissues could help to have more information about the correlation among methylation, SPARC expression and its possible role as predictive or prognostic maker in different disease stage. Here, SPARC is linked to lung cancer.