No difference in the SPARC methylation levels was observed between NLDT and NL of paired available 19 NSCLC tissues, whereas ordered differences were observed in the SPARC methylation level from the NL and the NLDT samples to the NSCLC samples (p = 0.002 and p = 0.0034 respectively; Wilcoxon signed rank test). The gene discussed is SPARC; the disease is non-small cell lung carcinoma.