The aim of the present study therefore was to investigate the role of reelin in schizophrenia by using a chronic Meth treatment paradigm [31,32] and assessing its effect on a number of schizophrenia-relevant endophenotypes in adulthood, including locomotor activity (both spontaneous and acute Meth induced), prepulse inhibition (PPI) and social interaction [33,34,35]. The gene discussed is RELN; the disease is schizophrenia.