Yao et al., using SDS (Sodium Dodecyl Sulphate) polyacrylamide gel electrophoresis (PAGE) and an electrospray ionization ion trap mass spectrometer, found that (Epidermal Growth Factor) EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) was highly upregulated in CRC patients. Here, EGF is linked to colorectal carcinoma.