Although this association is not well studied [32,33,34,35,36], in an experiment that was performed using an animal model of HER-2-positive breast cancer, CCL2, which is produced by cancer and myeloid cells, attracted macrophages to upregulate Wnt-1 and downregulate E-cadherin, resulting in cancer dissemination. This evidence concerns the gene ERBB2 and breast carcinoma.