The larger resting value of [NADH]M and smaller increase in response to cytosolic Ca2+ in MICU1 KO cells is consistent with observations where a larger concentration of NADH in resting state and smaller change in response to Histamine-induced rise in intracellular Ca2+ was observed in primary fibroblasts with MICU1 mutations in individuals with a disease phenotype characterized by proximal myopathy, learning difficulties, and a progressive extrapyramidal movement disorder as compared to those from age-matched healthy individuals [28]. The gene discussed is MICU1; the disease is movement disorder.