Since triple negative breast cancer tumors display an overexpression of HB-EGF, the conjugation of anti-HB-EGF antibody with LNPs (αHB-EGF LNP-siRNA) led to its increased tumor accumulation in MDA-MB-231 (triple negative breast cancer cell line) xenografted mice as compared to control LNPs after systemic administration. Here, HBEGF is linked to triple-negative breast carcinoma.