Furthermore, they found that EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1, also known as fibulin-3) played an inhibitory function of CIN triggered by low cell-plating density in vitro and low cell inoculum volume in vivo [161,162]. The gene discussed is EFEMP1; the disease is cervical squamous intraepithelial neoplasia.