Similarly, the migratory ability of hepatoma cells expressing higher levels of UHMK1 was also partially repressed by adding ERK inhibitor (Figure 8C–E), indicating that the ERK pathway was one of the downstream cascades modulated by COX5B-UHMK1 axis for regulation of cell proliferation and migration in hepatoma cells. The gene discussed is UHMK1; the disease is hepatocellular carcinoma.