As SAFB1 shares properties with RBPs known to be implicated in human neurodegenerative disease, is expressed at high levels in the cerebellum, translocates to nuclear stress bodies (nSBs) following the exposure of cells to a variety of stresses and binds ATXN1 we investigated its expression in SCAs alongside other neurodegenerative diseases. This evidence concerns the gene SAFB and neurodegenerative disease.