Genes involved in the cell cycle that were specific to tumor cycling KCs formed the largest network, centered around PCNA and GINS2. The largest TSK-specific network consisted of ITGB1, FERMT1, CD151, ARPC2, and HSP90B1. The protein products of ITGB1, CD151, and FERMT1 physically interact at the cell surface to mediate integrin signaling (Calderwood et al., 2013, Hemler, 2005). The gene discussed is TSKU; the disease is neoplasm.