To investigate the role of STC1 in lung adenoma/adenocarcinoma progression, we have analyzed two genetically engineered mouse (GEM) models: one driven by G12DKRAS leading to adenocarcinoma development (Sutherland et al., 2014), and the other by V600EBRAF generating pre-malignant adenomas (Kamata et al., 2015). This evidence concerns the gene STC1 and lung adenoma.