SPNS1 and microcephaly: Two homologs with significant eye phenotypes did not show any wing phenotypes, including SPNS1/spin within distal 16p11.2 and microcephaly-associated SLC25A19/Tpc1 [55], while five homologs only showed wing-specific phenotypes, including CDIPT/Pis and YPEL3/CG15309 within 16p11.2, FBXO45/Fsn and OSTalpha/CG6836 within 3q29, and UQCRC2/UQCR-C2 (Fig 5B, S3 Fig).