RHOA and renal fibrosis: TMSB4X also alleviates renal tubulointerstitial fibrosis and tubular cell apoptosis in a rat model of tubulointerstitial fibrosis [54], and in tubular epithelial cells from a rat model of renal fibrosis through the TGF-β pathway [55]; iii) MYH9 is an actin regulator via activation of RhoA whose deletion in mice was associated with fibrosis and proteinuria [56].