Mitochondrial expression of ABHD11 was confirmed by immunofluorescence in different cancer cell lines, expressing endogenous ABHD11 protein as breast adenocarcinoma MCF7 (Fig 2A) and hepatocellular carcinoma HepG2 or colon adenocarcinoma SW480, in which the native ABHD11 immuno-signal co-localizes with COX4 (data not shown for these two last cell lines). This evidence concerns the gene COX4I1 and hepatocellular carcinoma.