APOE and Alzheimer disease: The increased levels of the ionotropic receptor NMDA type subunit 1 (Grin1) is notable: a GRIN polymorphism is associated with the risks of Parkinson (Wu et al., 2010), schizophrenia (Demontis et al., 2011), and also interacts with APOE alleles for earlier AD onset (de Oliveira et al., 2016), GRIN variants might also alter air pollution neurodegenerative responses, for example mutations in GRIN2A and GRIN2B increased the risk of cognitive impairments for lead poisoning of children (Rooney et al., 2018b).