For non-exposed controls (baseline), APOE4 vs APOE3 differed in 300 genes related to known APOE pathways including LXR/RXR (Courtney and Landreth, 2016), Atherosclerosis (Mahley et al., 2009), and Rheumatoid arthritis (Toms et al., 2012). Here, APOE is linked to rheumatoid arthritis.