PARP1 and posterior cortical atrophy: Recently, there has been an emphasis on understanding the link between the DDR and AR, since radiation is a standard of care for locally advanced PCa where the AR is a major driver, and PARP inhibitors may be efficacious in CRPC patients with mutations in DDR genes (Polkinghorn et al., 2013; Goodwin et al., 2013; Ta et al., 2015; Mateo et al., 2015; Li et al., 2014; Yin et al., 2017a).