The T2DM‐associated risk potential of only four genes of our set [for FTO (Hubacek et al., 2018), IGF2BP2, (Gu et al., 2012), CDKN2A/2B (Hubáček et al., 2013), and TCF7L2 (Včelák et al., 2012)] was examined in the Czech majority population. The gene discussed is IGF2BP2; the disease is type 2 diabetes mellitus.