The polymorphic TLR3 rs3775291 A allele is associated with decreased possibility of spontaneous clearance of Hepatitis B surface antigen (HBsAg) and Hepatitis B e-antigen (HBeAg) in serum, and an increased risk of developing chronic hepatitis B. Haplotype analysis revealed that the variant rs3775291A presents the lowest possibility of clearance of HBsAg in serum.30 Here, TLR3 is linked to chronic hepatitis B virus infection.