For CD4+, CD8+ and FoxP3+ cells, there were also significant correlations between levels of infiltration in tumour stroma and tumour nests, but by contrast neither of these compartments showed significant correlations with infiltration at the tumour edge, suggesting that factors governing T cell infiltration differ between the intra-tumoural spaces and the tumour edge. The gene discussed is FOXP3; the disease is neoplasm.