Furthermore, by targeting the essential autophagic modulator beclin 1 with RNAi to inhibit autophagy and assessing the morphology of treated cells via EM, we found that ABA-treated glioblastoma cells exhibited features of either autophagic cell death as defined by the Nomenclature Committee on Cell Death (Galluzzi et al. 2012) or autophagy-associated cell death (AACD) as identified by Tasdemir et al. (Vicencio et al. 2008). The gene discussed is BECN1; the disease is glioblastoma.