Among the 2N patients, we detected six genes (POLR3F, SEC23B, ZNF133, C16orf45, RRN3, and NTAN1) which were overexpressed after irradiation and were duplicated in the genome of ALL patients with the second independent cancer being either meningioma or thyroid carcinoma. This evidence concerns the gene POLR3F and acute lymphoblastic leukemia.