NUP98 and myelodysplastic syndrome: For example, p53 deficiency synergizes with: Rb deficiency in a conditional mouse model to produce metastatic prostate cancer [19]; NUP98 translocation in a NUP98-HOXD13–driven mouse model to accelerate complications of myelodysplastic syndrome [20]; and mutations in Apc to promote mammary neoplasia [21].