This unexpected shift in tumor spectrum to thymic lymphomas is observed with TRP53 mutations in other strains such as C57BL6/J, 129S1, BALB/c, FVB/NJ, and C3H/J, suggesting that deregulation of TRP53 leads to specific types of cancers depending upon the genetic background [14-18]. The gene discussed is TP53; the disease is thymus lymphoma.