BHLHE40 and non-small cell lung carcinoma: However, a third study which examined 115 tumor samples from patients with NSCLC (78 SCC and 37 ADC), showed that in both types, BHLHE40 was strongly expressed in the nuclei of normal bronchial epithelium and submucosal vessels, whereas it’s immunoreactivity was frequently reduced in cancer cells compared with adjacent normal bronchi [84].