BHLHE40 and neoplasm: Loss of BHLHE40 was correlated with poor differentiation (p = 0.005) and high p-TNM stage (p = 0.002) while BHLHE40 expression negatively correlated with cyclin D1 expression (p = 0.014), suggesting that BHLHE40 may act as a tumor suppressor in NSCLC [64].