BHLHE40 and neoplasm: In another study, which analyzed 44 primary and 16 recurrent oligodendroglial neoplasms with 1p-aberrations, high BHLHE40 expression was observed in the cell nuclei in almost all (56 of 60) tumors, and occasionally in endothelial cells, as well as in glial and neuronal cells of surrounding brain tissue, compared to those away from the tumor [75].