Moreover, the expression levels of IFI16 (> threefold) and AIM2 (> fivefold) were increased to a much greater extent than those of NLRP3 (1.4-fold) and NOD1 (2.3-fold) in HNSCC versus the control buccal mucosas (Table 1). This evidence concerns the gene IFI16 and head and neck squamous cell carcinoma.