Then, GEPIA dataset was used to analyze the correlation between IFI16 and caspase-1 in HNSCC, and it was found that the level of IFI16 was positively correlated with the level of caspase-1 (R = 0.21, P < 0.01) (Fig. 2d). The gene discussed is IFI16; the disease is head and neck squamous cell carcinoma.