The knockout of TET1 could aggravate hepatic steatosis compared with WT mice (Fig. 2 d, e, f), which was consistent with body weight (Fig. 2 g), intrahepatic triglyceride (TG) (Fig. 2 h), serum TG (Fig. 2 l), cholesterol (Fig. 2 k), aspartate aminotransferase (AST) (Fig. 2 n) and alanine aminotransferase (ALT) (Fig. 2 o), all of which were significantly higher in TET1−/− mice. Here, TET1 is linked to Hepatic steatosis.