Interestingly, a clinical trial about obese subjects with metabolic syndrome showed that green tea minimally affects biomarkers of inflammation, including adiponectin, C-reactive protein (CRP), Interleukin- 6 (IL-6), Interleukin-1 beta (IL-1β), vascular cell adhesion molecule-1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), and leptin, but significantly reduces plasma amyloid alpha, an independent cardiovascular disease (CVD) risk factor (41). This evidence concerns the gene LEP and cardiovascular disorder.