NOS2 and metabolic dysfunction-associated steatohepatitis: In obese mice model of nonalcoholic steatohepatitis, the green tea intervention significantly reduces the expression levels of proinflammatory genes (TNFα, iNOS, monocyte chemotactic protein 1, MCP-1, myeloperoxidase, MPO) likely via limiting endotoxin translocation and TLR4/MyD88/NFκB activation along the gut-liver axis (39).