In TLR2, we observed that carriers of at least one C-T haplotype of rs3804099-rs3804100 had increased TB risk in comparison with the individuals carrying the homozygous T-T/T-T diplotype (aOR = 3.513; 95% CI = 1.550–7.962, p = 0.003). This evidence concerns the gene TLR2 and tuberculosis.