The amount of intra-tumor sXBP1 transcripts was significantly higher in tumors classified as “Mesenchymal” compared with those classified as “Epithelial”, whereas CHOP transcripts were similar between the 2 groups, (Fig. 3A and S4), suggesting that sXBP1 is associated with the transition to a mesenchymal phenotype. The gene discussed is DDIT3; the disease is neoplasm.