While the RB tumors or regions rich in B7H3 could benefit by use of anti-B7H3 drug conjugates26 or B7H3 Chimeric Antigen Receptor (CAR)- T cell strategy27 lower levels of B7H3 as seen in severe anaplastic regions of RB tumor or the tumor front invading the optic nerve might require an alternative strategy. Here, CD276 is linked to neoplasm.