CD276 and retinoblastoma: While the RB tumors or regions rich in B7H3 could benefit by use of anti-B7H3 drug conjugates26 or B7H3 Chimeric Antigen Receptor (CAR)- T cell strategy27 lower levels of B7H3 as seen in severe anaplastic regions of RB tumor or the tumor front invading the optic nerve might require an alternative strategy.