KRAS and pancreatic neoplasm: Gene ontology analysis using the list of 196 hypermethylated gene promoters, and 351 hypomethylated gene promoters in SAKRAS cells overexpressing KRAS G12V, showed an enrichment for genes involved in development and differentiation (Fig. 5), consistent with our previous mutant KRAS loss-of-function studies performed in pancreatic cancer cells (Fig. 3and Supplementary Fig. S6D,E).