TLR2 and infection: Similar results were yielded when TLR2 expression was stratified based on the infecting serotype; CM from patients who developed DHF/DSS following DENV1 and DENV2 infections showed significantly higher expression of TLR2 when compared to those who developed DF (P < 0.05, two-tailed Mann–Whitney test) (Supplementary Fig. 4a, b, respectively) while no differences were observed for IM and NM (Supplementary Fig. 4).