FMR1 and fragile X-associated tremor/ataxia syndrome: The premutation (55–200 CGG repeats) is associated with elevation of FMR1 mRNA (mRNA)5,6 and the development of neurological problems associated with aging, including the Fragile X-associated tremor ataxia syndrome (FXTAS)7,8 and fragile X-associated premature ovarian insufficiency (FXPOI)9.