It has been revealed that miR-495 can weaken EMT phenotype acquisition in nasopharyngeal carcinoma cells and enhance their radiosensitivity by downregulating the expression of the cell surface protein GRP78.158 Signal transducer and activator of transcription 3 (STAT3), an important transcription factor induced by EMT, has been found to play a role in increasing IR-induced CSCs in pancreatic cancer. This evidence concerns the gene STAT3 and familial pancreatic carcinoma.