In fact, as mentioned previously, many proteins, including PARP1, RPA70, TopBP1, ATR, ATRIP, BRCA1, and MDC1,33–35,37,38 have also been shown to be SUMOylated in response to DNA damage, and the SUMOylation of these proteins plays important roles in DNA repair and cell survival.31 This finding prompted us to test whether knocking out UBC9 or treating cells with 2-D08 and ML-792, which decreases global SUMOylation levels, would enhance the sensitivity of cancer cells to the chemotherapy drugs commonly used in the clinic, such as etoposide. The gene discussed is TOPBP1; the disease is cancer.