Moreover, CD8+ T-cell depletion via OKT8 treatment (Fig S2F and G) only exacerbated the EBV disease burden in EBV single-infected mice, whereas in EBV/HIV dual-infected animals, OKT8 treatment did not result in a further increase in tumor burden or EBV viral load (Fig 3E and F). Here, CD8A is linked to neoplasm.