To assess if EBV infection can induce CD4 expression in humans, we investigated PBMCs from healthy blood donors, patients with infectious mononucleosis, that is, the primary symptomatic infection with EBV, or EBV+ B cell posttransplant lymphoproliferative disorders (PTLDs) and found that patients with EBV-associated diseases had more frequent CD4+ B cells than controls (Fig 1E and Table S1). Here, CD4 is linked to infectious mononucleosis.