In line with the selective susceptibility of LCLs to X4-tropic HIV-1 infection, we found that a large fraction of the LCLs expressed CD4 on their surface and retained expression of CXCR4 at lower levels upon EBV transformation, whereas transcript levels of CCR5 were very low in selectively sequenced LCLs as previously reported (Figs 1C and S1D) (31, 32, 33). Here, CCR5 is linked to HIV-1 infection.