Previous studies found that, during the acute phase of SARS-CoV infection in humans, CD4+ and CD8+ T cell counts were decreased.22-24 SARS-CoV-2 also presented similar characteristics, because viral infection causes persistent consumption and/or insufficient regeneration of lymphocytes.19 Therefore, CD4+ and CD8+ T cell counts vary in response to SARS-CoV-2 infection in the acute phase and may be far from satisfactory for protection during the entire recovery period. Here, CD4 is linked to viral infectious disease.