Status of steroid and growth factor receptors expression such as Estrogen Receptor (ER), Progesterone Receptor (PR), and Hunan Epidermal Receptor-2 (HER2) play a key role in term of diagnosis and treatment of BC [16–18], since IL17 is directly related to production of steroid hormones and growth factors [9, 19, 20]. The gene discussed is ESR1; the disease is breast cancer.