SP1 and gastric cancer: To determine the significance of expressions both TRIM25 and SP1 in GC, using the online bioinformatics tool Kaplan-Meier Plotter (http://www.oncolnc.org/), we found that patients with a low level of TRIM25 in GC tissues suffer a poor overall survival (OS) than a high level of TRIM25 ones (Fig. 6a).