We further collected all available 7 lung cancer cell lines and found three of them carried the KEAP1 mutation (A549, NCI-H460, NCI-H838), thus, in the present study, all the seven lung cancer cell lines were used to study the influence of KEAP1 mutation on the function of KEAP1/NRF2 pathway. This evidence concerns the gene NFE2L2 and lung carcinoma.