To explore the effect of KEAP1 loss on activation of the KEAP1/NRF2 pathway, we collected three NSCLC cell lines with KEAP1 mutations (A549, NCI-H460, and NCI-H838) and four NSCLC cell lines without KEAP1/NRF2 mutations (NCI-H1299, NCI-H292, 95D, and SPCA1). This evidence concerns the gene ATP2C1 and non-small cell lung carcinoma.