Additionally, the tumor growth of the A549 cell line stably transfected with the R320Q KEAP1 mutant was strongly accelerated compared with that of the A549 cell line stably transfected with WT KEAP1, as measured by the change in tumor volume (Fig. 3b). Consistent with the in vitro results, the KEAP1 mutant showed significantly accelerated tumor growth in vivo. The gene discussed is KEAP1; the disease is neoplasm.