Interestingly, when the lung cancer cell lines were treated with ML385 at a low dose, such as 0.25 or 0.5 μM/L, the proliferation of theA549 lung cancer cell line transfected with the R320Q KEAP1 mutant showed more significant inhibition than that of A549 cells transfected with WT KEAP1 or that of H1299 lung cancer cells (Fig. 4a, b). This evidence concerns the gene KEAP1 and lung carcinoma.