The lung cancer cell line A549 transfected with the R320Q KEAP1 mutant (KEAP1-R320Q mutant) or with WT KEAP1 (KEAP1-WT) and H1299 lung cancer cells, which carry both WT KEAP1 and NRF2, were selected and treated with ML385. The gene discussed is NFE2L2; the disease is lung carcinoma.