We found a positive and significant correlation between the BR3+/CD14+ ratio and serum levels of IgG (r = 0.351, p = 0.0018; Fig. 3a) and IgM (r = 0.303, p = 0.0064; Fig. 2b), but no correlation between the proportion of CD14+ cells and serum IgG (r = 0.05, p = 0.343; Supplementary Fig. 4A) and IgM (r = − 0.077, p = 0.269; Supplementary Fig. 4B) in pSS patients. This evidence concerns the gene CD40LG and peeling skin syndrome.