The overall schematic mechanism is illustrated in Fig. 7 and indicates that ZNF322A-silenced A549 lung cancer cells trigger autophagy by glucose starvation and UPR through phosphorylation of IRS1S1101 and HSP27S82 to inhibit PI3K/AKT/mTOR pathways and to elicit heat stress. Here, ZNF322 is linked to lung cancer.