In our quantitative proteomic study of ZNF322A-silenced A549 lung cancer [7], we revealed that the majority of ZNF322A downstream proteins were involved in signal transduction and protein phosphorylation, thus, the ZNF322A-mediated phosphorylation network was established to better understand the mechanism and biological function of zinc-finger proteins in response to lung cancer. The gene discussed is ZNF322; the disease is lung cancer.