Taken together, we purpose that the depletion of ZNF322A in A549 lung cancer cells transcriptionally regulates PIM3 kinase to induce IRS1Ser1101 phosphorylation, which attenuates PI3K/AKT signaling pathway and inhibits AKTS473, leading to glucose uptake blockade (Fig. 4i). Here, AKT1 is linked to lung cancer.